abstract：:Use of chemosensory event-related potentials (ERPs) is limited by relatively poor signal-to-noise ratios (SNRs). We hypothesized that by reducing the standard inter-stimulus interval (ISI), the increased number of trial repetitions possible may increase SNR. In order to further investigate this, we performed the large...

journal_title：Neuroscience

authors： Whitcroft KL,Aziz M,Croy I,Schriever V,Hummel T

更新日期：2017-11-05 00:00:00

abstract：:The post-stroke angiogenic response is accompanied by changes of tight junctions (TJs) of the blood-brain barrier (BBB). However, the precise dynamic change of TJ proteins (TJPs) in the different stages of stroke-induced vascular remodeling and the molecules mediating these processes have yet to be fully defined. To i...

journal_title：Neuroscience

authors： Sun J,Yu L,Huang S,Lai X,Milner R,Li L

更新日期：2017-10-24 00:00:00

abstract：:Amyloid-β (Aβ) production and clearance in the brain is a crucial focus of investigations into the pathogenesis of Alzheimer disease. Imbalance between production and clearance leads to accumulation of Aβ. The important Aβ-degrading enzymes in the brain are neprilysin (NEP) and insulin-degrading enzyme (IDE), and defe...

journal_title：Neuroscience

authors： Yamamoto N,Shibata M,Ishikuro R,Tanida M,Taniguchi Y,Ikeda-Matsuo Y,Sobue K

更新日期：2017-10-24 00:00:00

abstract：:In the neocortex, interaction and cooperation between different areas are important for information processing, which also applies to different areas within one sensory modality. In the temporal cortex of rodents and cats, both the primary auditory cortex (A1) and the anterior auditory field (AAF) have tonotopicity bu...

journal_title：Neuroscience

authors： Zhang G,Tao C,Zhou C,Yan S,Wang Z,Zhou Y,Xiong Y

更新日期：2017-10-11 00:00:00

abstract：:Choline is essential to the development and function of the central nervous system and supplemental choline during development is neuroprotective against a variety of insults, including neurotoxins like dizocilpine (MK-801). MK-801 is an NMDA receptor antagonist that is frequently used in rodent models of psychologica...

journal_title：Neuroscience

authors： Nickerson CA,Brown AL,Yu W,Chun Y,Glenn MJ

更新日期：2017-10-11 00:00:00

abstract：:Following a Pavlovian pairing procedure, alcohol-paired cues come to elicit behavioral responses that lead to alcohol consumption. Here we used an optogenetic approach to activate basolateral amygdala (BLA) axonal terminals targeting the shell of nucleus accumbens (AcbSh) and investigated a possible influence over cue...

journal_title：Neuroscience

authors： Millan EZ,Kim HA,Janak PH

更新日期：2017-09-30 00:00:00

abstract：:Excessive inflammatory response produced after cardiac arrest and cardiopulmonary resuscitation (CA/CPR) is one of major causes of cerebral injury. High mobility group box 1 (HMGB1) is a pro-inflammatory cytokine and its role in brain injury after CA/CPR is unclear. Herein we investigated whether blocking HMGB1 signal...

journal_title：Neuroscience

authors： Shi X,Li M,Huang K,Zhou S,Hu Y,Pan S,Gu Y

更新日期：2017-09-30 00:00:00

abstract：:Skilled performance and acquisition is dependent upon afferent input to motor cortex. The present study used short-latency afferent inhibition (SAI) to probe how manipulation of sensory afference by attention affects different circuits projecting to pyramidal tract neurons in motor cortex. SAI was assessed in the firs...

journal_title：Neuroscience

authors： Mirdamadi JL,Suzuki LY,Meehan SK

更新日期：2017-09-17 00:00:00

abstract：:Locomotor networks after spinal cord injury (SCI) are shaped by training-activated proprioceptive and cutaneous inputs. Nociception from injured tissues may alter these changes but has largely been overlooked. The objective of the present study was to ascertain whether lumbar muscle inflammation hinders locomotion rec...

journal_title：Neuroscience

authors： Jeffrey-Gauthier R,Piché M,Leblond H

更新日期：2017-09-17 00:00:00

abstract：:The superior temporal gyrus (STG) is involved in speech recognition against informational masking under cocktail-party-listening conditions. Compared to healthy listeners, people with schizophrenia perform worse in speech recognition under informational speech-on-speech masking conditions. It is not clear whether the ...

journal_title：Neuroscience

authors： Li J,Wu C,Zheng Y,Li R,Li X,She S,Wu H,Peng H,Ning Y,Li L

更新日期：2017-09-17 00:00:00

abstract：:Neuro-anatomical evidence supports the potential for threat-related factors, such as fear, anxiety and vigilance, to influence brainstem motor nuclei controlling eye movements, as well as the vestibular nuclei. However, little is known about how threat influences human ocular responses, such as eye saccades (ES), smoo...

journal_title：Neuroscience

authors： Naranjo EN,Cleworth TW,Allum JHJ,Inglis JT,Lea J,Westerberg BD,Carpenter MG

更新日期：2017-09-17 00:00:00

abstract：:Functional imaging studies have implicated the hippocampus and parahippocampal gyrus in cue-guided spatial navigation, but also many other regions. Furthermore, little is known about de-activations that take place during performance of navigation tasks, something that is of interest given that the hippocampus is a com...

journal_title：Neuroscience

authors： Salgado-Pineda P,Landin-Romero R,Pomes A,Spanlang B,Sarró S,Salvador R,Slater M,McKenna PJ,Pomarol-Clotet E

更新日期：2017-09-01 00:00:00

abstract：:Recent evidence suggests that ischemia/reperfusion (I/R) in an organ may have distance effect on the brain. In this study, the effects of renal I/R, limb I/R or both together on the structural and function of hippocampus were evaluated and compared. Hence, rats were subjected to 2-h bilateral lower limb ischemia, 45-m...

journal_title：Neuroscience

authors： Karimi N,Haghani M,Noorafshan A,Moosavi SMS

更新日期：2017-09-01 00:00:00

abstract：:The application of subsensory noise stimulation over the lower limbs has been shown to improve proprioception and postural control under certain conditions. Whereas the effect specificity seems to depend on several factors, studies are still needed to determine the appropriate method for training and rehabilitation pu...

journal_title：Neuroscience

authors： Toledo DR,Barela JA,Kohn AF

更新日期：2017-09-01 00:00:00

abstract：:The NMDA receptor (NMDAr) hypofunction theory of schizophrenia suggests that aberrant signaling through NMDAr underlies the pathophysiology of this disease. This is commonly modeled in rodents via treatment with NMDAr antagonists, which causes a range of behavioral effects that represent endophenotypes related to schi...

journal_title：Neuroscience

authors： Lee J,Hudson MR,O'Brien TJ,Nithianantharajah J,Jones NC

更新日期：2017-09-01 00:00:00

abstract：:It has been suggested that the brain adopts a simplified strategy to coordinate a large number of degrees of freedom in motor control. Synergies have been proposed as a strategy to produce movements by recruitment of a small number of fixed modular patterns. However, there is no direct support for a synergistic organi...

journal_title：Neuroscience

authors： Hao Y,Zhang S,Zhang Q,Li G,Chen W,Zheng X

更新日期：2017-08-15 00:00:00

abstract：:Neuroscientists have often described the adult brain in similar terms to an electronic circuit board- dependent on fixed, precise connectivity. However, with the advent of technologies allowing chronic measurements of neural structure and function, the emerging picture is that neural networks undergo significant remod...

journal_title：Neuroscience

authors： Chambers AR,Rumpel S

更新日期：2017-08-15 00:00:00

abstract：:It is not known whether, during the course of aging, changes occur in the motor strategies used by the CNS for lifting objects of different weights. Here, we analyzed the kinematics of object-lifting in two different healthy groups (young and elderly people) plus one well-known deafferented patient (GL). The task was ...

journal_title：Neuroscience

authors： Hoellinger T,McIntyre J,Jami L,Hanneton S,Cheron G,Roby-Brami A

更新日期：2017-08-15 00:00:00

abstract：:Dysfunction of thalamo-cortical networks involving particularly the thalamic reticular nucleus (TRN) is implicated in schizophrenia. In the neonatal ventral hippocampal lesion (NVHL), a heuristic animal model of schizophrenia, brain oscillation changes similar to those of schizophrenic patients have been reported. The...

journal_title：Neuroscience

authors： Magdaleno-Madrigal VM,Contreras-Murillo G,Camacho-Abrego I,Negrete-Díaz JV,Valdés-Cruz A,Fernández-Mas R,Almazán-Alvarado S,Flores G

更新日期：2017-08-15 00:00:00

abstract：:Executive control requires behavioral adaptation to environmental contingencies. In the stop signal task (SST), participants exhibit slower go trial reaction time (RT) following a stop trial, whether or not they successfully interrupt the motor response. In previous fMRI studies, we demonstrated activation of the righ...

journal_title：Neuroscience

authors： Zhang Y,Ide JS,Zhang S,Hu S,Valchev NS,Tang X,Li CR

更新日期：2017-08-15 00:00:00

abstract：:The performance of a cochlear implant depends on the defined interaction between afferent neurons of the spiral ganglion and the inserted electrode. Neurite outgrowth can be induced by neurotrophins such as brain-derived neurotrophic factor (BDNF) via tropomyosin kinase receptor B (TrkB). However, neurotrophin signali...

journal_title：Neuroscience

authors： Kramer B,Tropitzsch A,Müller M,Löwenheim H

更新日期：2017-08-15 00:00:00

abstract：:The aim of the present study was to examine the modification of postural symmetry during quiet standing using a sensorimotor adaptation paradigm. A group of neurologically typical adult participants performed a visually guided mediolateral (left-right) weight shifting task requiring precise adjustments in body orienta...

journal_title：Neuroscience

authors： Shiller DM,Veilleux LN,Marois M,Ballaz L,Lemay M

更新日期：2017-07-25 00:00:00

abstract：:Chitinase activity is increased in Alzheimer's disease (AD). However, the role of chitinase1 in AD is unknown. We investigated the effects of chitinase1 on Alzheimer's pathology and microglia function. Artificial chitinase1 and chitinase inhibitor (chitinase-IN-2) were used to determine the effects of chitinase1 on in...

journal_title：Neuroscience

authors： Xiao Q,Yu W,Tian Q,Fu X,Wang X,Gu M,Lü Y

更新日期：2017-07-04 00:00:00

abstract：:Mutations in the PI3K/Akt/mTOR signaling pathway or in the upstream negative regulator Pten cause human brain overgrowth disorders, such as focal cortical dysplasia and megalencephaly, and are characterized by the presence of hypertrophic neurons. These disorders often have a pediatric onset and a high comorbidity wit...

journal_title：Neuroscience

authors： Nikolaeva I,Kazdoba TM,Crowell B,D'Arcangelo G

更新日期：2017-06-23 00:00:00

abstract：:The concentrations of fourteen neurochemicals associated with metabolism, neurotransmission, antioxidant capacity, and cellular structure were measured noninvasively from two distinct brain regions using 1H magnetic resonance spectroscopy. Seventeen young adults (age 19-22years) and sixteen cognitively normal older ad...

journal_title：Neuroscience

authors： Marjańska M,McCarten JR,Hodges J,Hemmy LS,Grant A,Deelchand DK,Terpstra M

更新日期：2017-06-23 00:00:00

abstract：:Brain microvascular endothelial cell (BMEC) injury induced by ischemia-reperfusion (I/R) is the initial stage of blood-brain barrier (BBB) disruption, which results in a poor prognosis in ischemic stroke patients. Autophagy has been shown to have protective effects on BMECs against cerebral ischemic insults. However, ...

journal_title：Neuroscience

authors： Li Z,Li J,Tang N

更新日期：2017-06-23 00:00:00

abstract：:In the present study, we investigated the possible participation of the endocannabinoid system in the basolateral amygdala and N-methyl-d-aspartate (NMDA) or GABA-A receptor neurotransmission in the ventral tegmental area in the memory consolidation impairment induced by morphine administration. To measure memory form...

journal_title：Neuroscience

authors： Sharifi KA,Rezayof A,Torkaman-Boutorabi A,Zarrindast MR

更新日期：2017-06-14 00:00:00

abstract：:Ocular dominance has been extensively studied, often with the goal to understand neuroplasticity, which is a key characteristic within the critical period. Recent work on monocular deprivation, however, demonstrates residual neuroplasticity in the adult visual cortex. After deprivation of patterned inputs by monocular...

journal_title：Neuroscience

authors： Bai J,Dong X,He S,Bao M

更新日期：2017-06-03 00:00:00

abstract：:Semaphorins comprise a family of proteins involved in axon guidance during development. Semaphorin4D (Sema4D) has both neuroregenerative and neurorepressive functions, being able to stimulate both axonal outgrowth and growth cone collapse during development, and therefore could play an important role in neurological r...

journal_title：Neuroscience

authors： Peng SX,Yao L,Cui C,Zhao HD,Liu CJ,Li YH,Wang LF,Huang SB,Shen YQ

更新日期：2017-05-20 00:00:00

abstract：:The study explored unintentional force changes elicited by removing visual feedback during cyclical, two-finger isometric force production tasks. Subjects performed two types of tasks at 1Hz, paced by an auditory metronome. One - Force task - required cyclical changes in total force while maintaining the sharing, defi...

journal_title：Neuroscience

authors： Reschechtko S,Hasanbarani F,Akulin VM,Latash ML

更新日期：2017-05-14 00:00:00

abstract：:The trigeminal ganglia (TG) subserving the head and the dorsal root ganglia (DRG) subserving the rest of the body are homologous handling sensory neurons. Differences exist, as a number of signaling substances cause headache but no pain in the rest of the body. To date, very few genes involved in this difference have ...

journal_title：Neuroscience

authors： Kogelman LJA,Christensen RE,Pedersen SH,Bertalan M,Hansen TF,Jansen-Olesen I,Olesen J

更新日期：2017-05-14 00:00:00

abstract：:During the early developmental period, long-term potentiation (LTP) can be induced in both vertical and horizontal connections in the rat visual cortex. However, the temporal difference in LTP change between the two pathways during animal development remains unclear. In this study, LTP in vertical (from layer IV to la...

journal_title：Neuroscience

authors： Li DK,Zhang C,Gu Y,Zhang SH,Shi J,Chen XH

更新日期：2017-05-14 00:00:00

abstract：:Fragile X mental retardation protein (FMRP), an important RNA-binding protein responsible for fragile X syndrome, is involved in posttranscriptional control of gene expression that links with brain development and synaptic functions. Here, we reveal a novel role of FMRP in pre-mRNA alternative splicing, a general even...

journal_title：Neuroscience

authors： Zhou LT,Ye SH,Yang HX,Zhou YT,Zhao QH,Sun WW,Gao MM,Yi YH,Long YS

更新日期：2017-05-04 00:00:00

abstract：:Pain is processed in a large neural network that partially overlaps structures involved in emotion processing. Despite the fact that pain and emotion are known to share neural regions and interact in numerous clinical conditions, relatively little is known about the interaction of pain and emotion at the neural level....

journal_title：Neuroscience

authors： Orenius TI,Raij TT,Nuortimo A,Näätänen P,Lipsanen J,Karlsson H

更新日期：2017-05-04 00:00:00

abstract：:Humans perform object recognition effortlessly and accurately. However, it is unknown how the visual system copes with variations in objects' appearance and the environmental conditions. Previous studies have suggested that affine variations such as size and position are compensated for in the feed-forward sweep of vi...

journal_title：Neuroscience

authors： Karimi-Rouzbahani H,Bagheri N,Ebrahimpour R

更新日期：2017-05-04 00:00:00

abstract：:The aim of the present study was to determine whether thoracic spinal manipulation (SM) decreases temporal summation of back pain. The study comprised two controlled experiments including 16 and 15 healthy participants, respectively. Each study included six sessions during which painful or non-painful electrical stimu...

journal_title：Neuroscience

authors： Randoll C,Gagnon-Normandin V,Tessier J,Bois S,Rustamov N,O'Shaughnessy J,Descarreaux M,Piché M

更新日期：2017-05-04 00:00:00

abstract：:We employed simultaneous field potential recordings from CA3, subiculum and entorhinal cortex in an in vitro brain slice preparation to understand the involvement of these limbic areas in the generation of the field potential oscillations that are induced by bath application of the muscarinic receptor agonist carbacho...

journal_title：Neuroscience

authors： Lévesque M,Cataldi M,Chen LY,Hamidi S,Avoli M

更新日期：2017-04-21 00:00:00

abstract：:Some studies have demonstrated that aging is associated with impaired vestibular reflexes, especially otolithic reflexes, resulting in postural instability. However, the neurochemical basis of these age-related changes is still poorly understood. The l-arginine metabolic system has been implicated in changes in the br...

journal_title：Neuroscience

authors： Liu P,Gupta N,Jing Y,Collie ND,Zhang H,Smith PF

更新日期：2017-04-21 00:00:00

abstract：:Social bonds, especially attachment relationships, are crucial to our health and happiness. However, what we know about the neural substrates of these bonds is almost exclusively limited to rodent models and correlational experiments in humans. Here, we used socially monogamous non-human primates, titi monkeys (Callic...

journal_title：Neuroscience

authors： Maninger N,Hinde K,Mendoza SP,Mason WA,Larke RH,Ragen BJ,Jarcho MR,Cherry SR,Rowland DJ,Ferrer E,Bales KL

更新日期：2017-04-21 00:00:00

abstract：:Early experience and social context interact to alter the phenotype of complex social behaviors. These early experiences can also result in alterations to cortical organization and connections. Given the ability of the neuropeptide oxytocin (OT) to modulate social and reproductive behavior, OT is likely involved in th...

journal_title：Neuroscience

authors： Duchemin A,Seelke AM,Simmons TC,Freeman SM,Bales KL

更新日期：2017-04-21 00:00:00